Lipidated Peptidomimetics with Improved Antimicrobial Activity
Digital Object Identifier (DOI)
We report a series of lipidated α-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated α-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the clinical candidate pexiganan as well as previously reported linear α-AApeptides. The further development of lipidated α-AApeptides will lead to a new class of antibiotics to combat drug resistance.
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Citation / Publisher Attribution
ACS Medicinal Chemistry Letters, v. 3, issue 8, p. 683-686
Scholar Commons Citation
Hu, Yaogang; Amin, Mohamad Nassir; Padhee, Shruti; Wang, Rongsheng E.; Qiao, Qiao; Bai, Ge; Li, Yaqong; Mathew, Archana; Cao, Chuanhai; and Cai, Jianfeng, "Lipidated Peptidomimetics with Improved Antimicrobial Activity" (2012). Chemistry Faculty Publications. 160.