Title

Lipidated Peptidomimetics with Improved Antimicrobial Activity

Document Type

Article

Publication Date

2012

Digital Object Identifier (DOI)

https://doi.org/10.1021/ml3001215

Abstract

We report a series of lipidated α-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated α-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the clinical candidate pexiganan as well as previously reported linear α-AApeptides. The further development of lipidated α-AApeptides will lead to a new class of antibiotics to combat drug resistance.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

ACS Medicinal Chemistry Letters, v. 3, issue 8, p. 683-686

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