Lipidated Peptidomimetics with Improved Antimicrobial Activity

Authors

Yaogang Hu, University of South Florida
Mohamad Nassir Amin, University of South Florida
Shruti Padhee, University of South Florida
Rongsheng E. Wang, University of South Florida
Qiao Qiao, University of South Florida
Ge Bai, University of South Florida
Yaqong Li, University of South Florida
Archana Mathew, University of South Florida
Chuanhai Cao, University of South FloridaFollow
Jianfeng Cai, University of South FloridaFollow

Document Type

Article

Publication Date

2012

Digital Object Identifier (DOI)

https://doi.org/10.1021/ml3001215

Abstract

We report a series of lipidated α-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated α-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the clinical candidate pexiganan as well as previously reported linear α-AApeptides. The further development of lipidated α-AApeptides will lead to a new class of antibiotics to combat drug resistance.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

ACS Medicinal Chemistry Letters, v. 3, issue 8, p. 683-686

Scholar Commons Citation

Hu, Yaogang; Amin, Mohamad Nassir; Padhee, Shruti; Wang, Rongsheng E.; Qiao, Qiao; Bai, Ge; Li, Yaqong; Mathew, Archana; Cao, Chuanhai; and Cai, Jianfeng, "Lipidated Peptidomimetics with Improved Antimicrobial Activity" (2012). Chemistry Faculty Publications. 160.
https://digitalcommons.usf.edu/chm_facpub/160