Stereoselective Radical Amination of Electron-Deficient C(sp3)–H Bonds by Co(II)-Based Metalloradical Catalysis: Direct Synthesis of α-Amino Acid Derivatives via α-C–H Amination
Document Type
Article
Publication Date
2012
Digital Object Identifier (DOI)
https://doi.org/10.1021/ol302511f
Abstract
The cobalt(II) complex of 3,5-DitBu-IbuPhyrin, [Co(P1)], is an effective catalyst for intramolecular amination of electron-deficient C–H bonds, including those adjacent to electron-withdrawing CO2R, C(O)NR2, C(O)R, and CN groups, in excellent yields with high regio- and stereoselectivity. The [Co(P1)]-catalyzed amination system provides a direct method for the synthesis of α-amino acid derivatives from the corresponding carboxylate precursors.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Organic Letters, v. 14, issue 19, p. 5158-5161
Scholar Commons Citation
Lu, Hongjian; Hu, Yang; Jiang, Huiling; Wojtas, Lukasz; and Zhang, X. Peter, "Stereoselective Radical Amination of Electron-Deficient C(sp3)–H Bonds by Co(II)-Based Metalloradical Catalysis: Direct Synthesis of α-Amino Acid Derivatives via α-C–H Amination" (2012). Chemistry Faculty Publications. 159.
https://digitalcommons.usf.edu/chm_facpub/159
