Title

Stereoselective Radical Amination of Electron-Deficient C(sp3)–H Bonds by Co(II)-Based Metalloradical Catalysis: Direct Synthesis of α-Amino Acid Derivatives via α-C–H Amination

Document Type

Article

Publication Date

2012

Digital Object Identifier (DOI)

https://doi.org/10.1021/ol302511f

Abstract

The cobalt(II) complex of 3,5-DitBu-IbuPhyrin, [Co(P1)], is an effective catalyst for intramolecular amination of electron-deficient C–H bonds, including those adjacent to electron-withdrawing CO2R, C(O)NR2, C(O)R, and CN groups, in excellent yields with high regio- and stereoselectivity. The [Co(P1)]-catalyzed amination system provides a direct method for the synthesis of α-amino acid derivatives from the corresponding carboxylate precursors.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Organic Letters, v. 14, issue 19, p. 5158-5161

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