Title

Accessing Alternative Reaction Pathways of the Intermolecular Condensation between Homo-propargyl Alcohols and Terminal Alkynes through Divergent Gold Catalysis

Document Type

Article

Publication Date

2017

Digital Object Identifier (DOI)

https://doi.org/10.1039/C6CC09794D

Abstract

An intermolecular condensation of alkynols and terminal alkynes is reported. Using IPrAuNTf2, an efficient Au-catalyzed cyclization–alkynylation strategy furnishes (2-arylalkynyl) cyclic ethers in moderate to excellent yields (up to 94%). This strategy is extended to the synthesis of functionalized 2,3-dihydrooxepines via the sequential Au-catalyzed ring expansion of the cyclic ether substrates.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Chemical Communication, v. 53, p. 2315-2318

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