Digital Object Identifier (DOI)
For the first time, α-formyldiazoacetates have been successfully applied for the asymmetric cyclopropanation of alkenes via Co(II)-based metalloradical catalysis. The cobalt(II) complex of the D2-symmetric chiral amidoporphyrin [Co(3,5-DitBu-ChenPhyrin)] is an effective metalloradical catalyst that can activate α-formyldiazoacetates to cyclopropanate both aromatic and aliphatic olefins with varied electronic properties, affording the synthetically useful 1,1-cyclopropaneformylesters in high yields with both high diastereo- and enantioselectivity.
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Citation / Publisher Attribution
Chemical Science, v. 8, issue 6, p. 4347-4351
Scholar Commons Citation
Xu, Xue; Wang, Yong; Cui, Xin; Wojtas, Lukasz; and Zhang, X. Peter, "Metalloradical Activation of Α-formyldiazoacetates for the Catalytic Asymmetric Radical Cyclopropanation of Alkenes" (2017). Chemistry Faculty Publications. 106.