Evolution and Disorder
Document Type
Article
Publication Date
2011
Digital Object Identifier (DOI)
https://doi.org/10.1016/j.sbi.2011.02.005
Abstract
The evolution of disordered proteins or regions of proteins differs from that of ordered proteins because of the differences in their sequence composition, intramolecular contacts, and function. Recent assessments of disordered protein evolution at the sequence, structural, and functional levels support this hypothesis. Disordered proteins have a different pattern of accepted point mutations, exhibit higher rates of insertions and deletions, and generally, but not always, evolve more rapidly than ordered proteins. Even with these high rates of sequence evolution, a few examples have shown that disordered proteins maintain their flexibility under physiological conditions, and it is hypothesized that they maintain specific structural ensembles.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Current Opinion in Structural Biology, v. 21, issue 3, p. 441-446
Scholar Commons Citation
Brown, Celeste J.; Johnson, Audra K.; Dunker, A. Keith; and Daughdrill, Gary W., "Evolution and Disorder" (2011). Molecular Biosciences Faculty Publications. 161.
https://digitalcommons.usf.edu/bcm_facpub/161
