A New DNA-binding Motif in the Skn-1 Binding Domain–DNA Complex
Document Type
Article
Publication Date
1998
Digital Object Identifier (DOI)
https://doi.org/10.1038/nsb0698-484
Abstract
The DNA-binding domain of Skn-1, a developmental transcription factor that specifies mesoderm in C. elegans. is shown by X-ray crystallography to have a novel fold in which a compact, monomeric, four-helix unit organizes two DNA-contact elements. At the C-terminus, a helix extends from the domain to occupy the major groove of DNA in a manner similar to bZip proteins. Skn-1, however, lacks the leucine zipper found in all bZips. Additional contacts with the DNA are made by a short basic segment at the N-terminus of the domain, reminiscent of the ‘homeodomain arm’.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Nature Structural & Molecular Biology, v. 5, p. 484-491
Scholar Commons Citation
Rupert, Peter B.; Daughdrill, Gary W.; Bowerman, Bruce; and Matthews, Brian W., "A New DNA-binding Motif in the Skn-1 Binding Domain–DNA Complex" (1998). Molecular Biosciences Faculty Publications. 146.
https://digitalcommons.usf.edu/bcm_facpub/146
