The Mevalonate Auxotrophic Mutant of Staphylococcus aureus Can Adapt to Mevalonate Depletion
Document Type
Article
Publication Date
2020
Digital Object Identifier (DOI)
https://doi.org/10.1128/aac.00726-13
Abstract
In this study, we attempted to adopt the auxotrophic mevalonate synthase mutant (ΔmvaS mutant) of Staphylococcus aureus to study whether a nongrowing but viable cell population is tolerant to bactericidal antibiotics. The mevalonate-depleted nongrowing ΔmvaS mutant was found tolerant to antibiotics. Surprisingly, after prolonged cultivation, we obtained stable ΔmvaS variants that were able to grow without mevalonate, which suggested unknown mechanisms for compensating undecaprenyl pyrophosphate production without mevalonate in S. aureus.
Was this content written or created while at USF?
No
Citation / Publisher Attribution
American Society for Microbiology, v. 57, issue 11, p. 5710-5713
Scholar Commons Citation
Yu, Wenqi; Leibig, Martina; Schäfer, Tina; Bertram, Ralph; Ohlsen, Knut; and Götz, Friedrich, "The Mevalonate Auxotrophic Mutant of Staphylococcus aureus Can Adapt to Mevalonate Depletion" (2020). Molecular Biosciences Faculty Publications. 127.
https://digitalcommons.usf.edu/bcm_facpub/127
