Document Type

Article

Publication Date

2017

Keywords

preeclampsia, intrinsically disordered proteins, structural proteomics, bioinformatics, antimicrobial peptides, polarity index method, lipoproteins, angiogenesis proteins

Digital Object Identifier (DOI)

https://doi.org/10.18388/abp.2016_1300

Abstract

Preeclampsia, hemorrhage, and infection are the leading causes of maternal death in underdeveloped countries. Since several proteins associated with preeclampsia are known, we conducted a computational study in which evaluated the commonness and potential functionality of intrinsic disorder in these proteins and also made an attempt to characterize their origin. To this end, we used a several supervised techniques, as a Polarity Index Method (PIM), which evaluates the electronegativity of proteins from their sequence alone. Peculiarities of resulting polar profile of the group of preeclampsia-related proteins were then compared with profiles of a group of lipoproteins, antimicrobial peptides, angiogenesis-related proteins, and the intrinsically disorder proteins. Our results showed a high graphical correlation between preeclampsia proteins, lipoproteins, and the angiogenesis proteins. These results lead us to strongly assume that the preeclampsia proteins are lipoproteins. We also show that several preeclampsia-related proteins contain significant amounts of functional disorder.

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Creative Commons License
This work is licensed under a Creative Commons Attribution-Share Alike 4.0 License.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Acta Biochimica Polonica, v. 64, issue 1, p. 99-111

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1300-Article Text-1356-1-10-20170327.pdf (6308 kB)
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