Poster Preview
College
College of Arts & Sciences
Mentor Information
Shawn Landry
Description
Postoperative wound infections remain a major clinical challenge, worsened by rising antibiotic resistance and passive dressings that fail to reduce bacterial growth. Antimicrobial blue light near 405 nanometers shows broad-spectrum bactericidal activity, yet most prior approaches use short, high-intensity illumination from stationary sources rather than continuous, wearable delivery. This study evaluates a wearable 405-nanometer blue-light bandage designed for continuous, low-intensity exposure suited to prolonged wound-adjacent use. Antimicrobial performance was assessed in vitro using Micrococcus luteus, a safe model organism, comparing continuous exposure to matched dark controls. Exposure produced a pronounced, time-dependent reduction in bacterial viability, with near-complete suppression of detectable colonies by thirty minutes, sustained at longer durations, while controls remained stable. These results support the feasibility of a wearable, continuous blue-light platform as a non-pharmacologic strategy for wound infection prevention, warranting further evaluation against significant drug-resistant pathogens.
In Vitro Evaluation of a 405-nm Blue-Light–Emitting Antimicrobial Bandage Using Micrococcus luteus
Postoperative wound infections remain a major clinical challenge, worsened by rising antibiotic resistance and passive dressings that fail to reduce bacterial growth. Antimicrobial blue light near 405 nanometers shows broad-spectrum bactericidal activity, yet most prior approaches use short, high-intensity illumination from stationary sources rather than continuous, wearable delivery. This study evaluates a wearable 405-nanometer blue-light bandage designed for continuous, low-intensity exposure suited to prolonged wound-adjacent use. Antimicrobial performance was assessed in vitro using Micrococcus luteus, a safe model organism, comparing continuous exposure to matched dark controls. Exposure produced a pronounced, time-dependent reduction in bacterial viability, with near-complete suppression of detectable colonies by thirty minutes, sustained at longer durations, while controls remained stable. These results support the feasibility of a wearable, continuous blue-light platform as a non-pharmacologic strategy for wound infection prevention, warranting further evaluation against significant drug-resistant pathogens.
