Document Type
Patent
Publication Date
January 2016
Patent Number
9241975
CPC
A61K 38/1709(20130101), A61K 38/53(20130101)
Abstract
Disclosed are methods of influencing, and enhancing, cognitive function by increasing, and/or preventing interference with, Reelin levels as well as Reelin signaling. Cognitive function is improved, in a subject in need thereof, by administering a therapeutically effective amount of Reelin, a Reelin-specific modulator or an agonist of a lipoprotein receptor to the subject. The lipoprotein receptor can be selected from candidates such as ApoER2 and VLDLR. As disclosed herein, agonists of the lipoprotein receptor for use with the inventive method include APC, Sep and Fc-RAP. In addition to administering exogenous Reelin, a Reelin-specific modulator, such as a recombinant Reelin fragment, can be used to increase Reelin levels and/or signaling.
Application Number
13/206,174
Recommended Citation
Weeber, Edwin; Zhao, Lisa; and Peters, Melinda, "Reelin rescues congnitive function" (2016). USF Patents. 78.
https://digitalcommons.usf.edu/usf_patents/78
Assignees
University of South Florida
Filing Date
08/09/2011
