Alzheimer’s Disease and Its Causes
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Mentor Information
Dr. Olukemi Akintewe
Description
Alzheimer’s disease (AD) is a neurodegenerative disease that causes loss of motor control, cognitive abilities, and memory loss. As AD continues to rise with the aging population, various lifestyle factors can contribute to the ultimate prevention of this disease. A systematic review was conducted to examine the impacts of diet, exercise, amyloid beta protein effect, tau accumulation, and histamine medications on reducing AD risk. Data was derived from the PubMed, Science Direct, MDPI, and SpringerLink databases. From this comprehensive study, it was found that many of these factors are correlated to decrease AD risk, such as the finding that exercise had been found to reduce amyloid beta protein accumulation in the brain and neuroinflammation. In addition, adherence to the Mediterranean and ketogenic diets were found to inhibit different aspects of AD developmental pathology, which included tau protein and amyloid beta accumulation that were generally found at high levels in AD patients. Usage of histamine medications was the only factor that was found to impact different parts of AD pathology, which focused mainly on prevention against neuron and cell damage.While the association of these factors has been found to decrease risk of AD, further studies would need to be conducted to allow for complete prevention of AD and potential treatments for individuals who have AD.
Alzheimer’s Disease and Its Causes
Alzheimer’s disease (AD) is a neurodegenerative disease that causes loss of motor control, cognitive abilities, and memory loss. As AD continues to rise with the aging population, various lifestyle factors can contribute to the ultimate prevention of this disease. A systematic review was conducted to examine the impacts of diet, exercise, amyloid beta protein effect, tau accumulation, and histamine medications on reducing AD risk. Data was derived from the PubMed, Science Direct, MDPI, and SpringerLink databases. From this comprehensive study, it was found that many of these factors are correlated to decrease AD risk, such as the finding that exercise had been found to reduce amyloid beta protein accumulation in the brain and neuroinflammation. In addition, adherence to the Mediterranean and ketogenic diets were found to inhibit different aspects of AD developmental pathology, which included tau protein and amyloid beta accumulation that were generally found at high levels in AD patients. Usage of histamine medications was the only factor that was found to impact different parts of AD pathology, which focused mainly on prevention against neuron and cell damage.While the association of these factors has been found to decrease risk of AD, further studies would need to be conducted to allow for complete prevention of AD and potential treatments for individuals who have AD.
