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Novel L-Ergothioneine Treatments with Antioxidant/Anti Inflammatory Effects Improve Hearing in Geriatric Male Mice in CBA/CaJ Mice

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Tampa

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Dr. Robert Frisina

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Presbycusis, also known as age-related hearing loss, is gradual hearing loss that occurs as people grow older. There are many causes of age-related hearing loss, but one cause includes cochlear oxidative stress. Free radicals of oxygen or reactive oxygen species accumulate in the ear as a byproduct of many biochemical pathways. The buildup of byproducts causes oxidative stress on the cochlea, resulting in damages. Antioxidants are substances that neutralize the free radicals that cause oxidative stress. L-Ergothioneine is a naturally derived antioxidant and shows therapeutic potential in many health issues regarding oxidative stress, including Alzheimer’s disease, liver damage, and heart disease. A study was designed to determine if the naturally derived anti-inflammatory antioxidant L-ergothioneine can be used to prevent presbycusis. The male and female CBA/Caj mice were divided into three groups for testing: control, low-dose (35mg/kg), and high-dose (70mg/kg). Hearing tests using ABRs were performed on a monthly basis over six months after the initial baseline measurement. The data was then analyzed by determining the threshold at each frequency and the intensity of wave I that reflects the response of the cochlear nerve. After baseline testing, males’ hearing improved in ways that varied by dosage, whereas females’ hearing did not improve and may have worsened. This suggests that EGT may have a future as an ARHL progression treatment derived from nature.

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Novel L-Ergothioneine Treatments with Antioxidant/Anti Inflammatory Effects Improve Hearing in Geriatric Male Mice in CBA/CaJ Mice

Presbycusis, also known as age-related hearing loss, is gradual hearing loss that occurs as people grow older. There are many causes of age-related hearing loss, but one cause includes cochlear oxidative stress. Free radicals of oxygen or reactive oxygen species accumulate in the ear as a byproduct of many biochemical pathways. The buildup of byproducts causes oxidative stress on the cochlea, resulting in damages. Antioxidants are substances that neutralize the free radicals that cause oxidative stress. L-Ergothioneine is a naturally derived antioxidant and shows therapeutic potential in many health issues regarding oxidative stress, including Alzheimer’s disease, liver damage, and heart disease. A study was designed to determine if the naturally derived anti-inflammatory antioxidant L-ergothioneine can be used to prevent presbycusis. The male and female CBA/Caj mice were divided into three groups for testing: control, low-dose (35mg/kg), and high-dose (70mg/kg). Hearing tests using ABRs were performed on a monthly basis over six months after the initial baseline measurement. The data was then analyzed by determining the threshold at each frequency and the intensity of wave I that reflects the response of the cochlear nerve. After baseline testing, males’ hearing improved in ways that varied by dosage, whereas females’ hearing did not improve and may have worsened. This suggests that EGT may have a future as an ARHL progression treatment derived from nature.