Biological Stress Response Terminology: Integrating the Concepts of Adaptive Response and Preconditioning Stress within a Hormetic Dose-Response Framework
Hormesis, Adaptive response, Conditioning, Preconditioning, Postconditioning, Stress response, Dose–response, Biphasic, U-shaped
Digital Object Identifier (DOI)
Many biological subdisciplines that regularly assess dose–response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose–response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose–response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.
Citation / Publisher Attribution
Toxicology and Applied Pharmacology, v. 222, issue 1, p. 122-128
Scholar Commons Citation
Diamond, David M., "Biological Stress Response Terminology: Integrating the Concepts of Adaptive Response and Preconditioning Stress within a Hormetic Dose-Response Framework" (2007). Psychology Faculty Publications. 1350.