We examined cultural and environmental factors affecting species diversity of home gardens in Amazonian Northeast Peru based on 33 surveys conducted in July/August, 2014, in three communities varying in remoteness, demography, ecological zone, and ethnicity. The results support the idea that community variation in home gardens is not influenced by a single factor such as remoteness, but instead is the result of multiple cultural and environmental factors. Similar to other studies of Amazonian home gardens, fruits and medicinal plants make up the bulk of home garden diversity; however, we did not find an association between a tourism and reduced garden diversity.