Graduation Year


Document Type




Degree Name

Doctor of Philosophy (Ph.D.)

Degree Granting Department


Major Professor

Jianfeng Cai, Ph.D.

Committee Member

James Leahy, Ph.D.

Committee Member

Kirpal Bisht, Ph.D.

Committee Member

Feng Cheng, Ph.D.


antimicrobial agents, drug resistance, OBTC library, helix mimics


Peptidomimetics are small protein like chains which can mimic primary, secondary or eventertiary structures of peptides. They have been attracting more and more attention because of their special advantages, such as high tolerance to proteolytic degradation and thousands of chemical diversities. γ-AApeptides were developed by our group as a kind of peptidomimetics that represent γ-substituted-N-acylated-N-aminoethyl amino acids. Many biological functions of γ-AApeptides have already been discovered. To expand the potential application of γ-AApeptides, I designed and synthesized three series of antimicrobial derivatives with broad-spectrum of antibacterial activity. A one-bead-two-compound thioether bridged macrocyclic γ-AApeptides library was built and screened against NRF2 protein. Moreover, γ-AApeptides sequences mimicking MLL and c-Myb protein were designed and synthesized to inhibit their protein-protein interaction with KIX domain.