Graduation Year
2020
Document Type
Thesis
Degree
M.S.
Degree Name
Master of Science (M.S.)
Degree Granting Department
Graduate School
Major Professor
Shyam Mohapatra, Ph.D.
Committee Member
Subhra Mohapatra, Ph.D.
Committee Member
Eleni Markoutsa, Ph.D.
Keywords
Lung Cancer, Microparticle, Nanoparticle, Sustained release, Telmisartan
Abstract
Lung cancer remains the leading cause of cancer-related mortality in men and women worldwide (National Comprehensive Cancer Network). Hence, developing an effective new therapy to treat lung cancer is under intense investigation. Specifically, the sustained release of a drug in lung tumors is critically important. Previous studies at the USF have shown that telmisartan exhibits synergistic properties when combined with Actinomycin-D for lung cancer treatment. The objective of this study is to develop a novel micro/nano system consisting of lipids and chitosan polymers that would be able to deliver Tel directly to the lungs and release its payloads in a targeted and controlled way. To achieve this, in this study we report the synthesis and in vitro characterization of a novel nano-in-micro platform. First, telmisartan is entrapped in chitosan for sustained drug release. For this purpose, Telmisartan-loaded tri-poly phosphate (TPP)- crosslinked chitosan NPs are loaded onto liposomal microparticles for effective lung accumulation.
The size and morphology of this micro/nano-system were characterized via DLS and
TEM. The size distribution and zeta potential of telmisartan loaded chitosan-TPP nanoparticle was found to be 160 ± 5 nm with PDI 0.1 ± 0.05 and 20mV, respectively. The encapsulation of telmisartan into chitosan-TPP nanoparticle was 100 %. The chitosan-TPP nanoparticle showed sustained release of telmisartan. In-vivo studies demonstrated a high accumulation of this micro/nano-system in the lungs after intravenous administration. Taken together, these results indicate that micro-in
nanoparticles permit sustained release of telmisartan.
Scholar Commons Citation
Jadhav, Heta N., "A Micro-Nano Particle System for Sustained Drug Release in Lung Cancer Therapy" (2020). USF Tampa Graduate Theses and Dissertations.
https://digitalcommons.usf.edu/etd/8948
