Graduation Year


Document Type




Degree Granting Department


Major Professor

Wei Chen, Ph.D.

Committee Member

Myung Kim, Ph.D.

Committee Member

Garrett Matthews, Ph.D.


Liquid chromatography, Human skin, Skin conductance, Benadryl, Diphenhydramine hydrochloride


Although an iontophoretic trans-dermal drug delivery is known as an effective means for drug transportation through the human skin, it is not widely used because of the various side effects that come to life due to a high applied voltage of up to 80V. This study introduces an alternative means of drug transportation through the skin by means of sweat gland activation and reduction of an applied voltage to ensure that the iontophoresis is safe. The skin conductance studies performed on the pulmar area using 50mM of NaCl showed that the activation of sweat glands led to the increase of the skin conductance up to 8-10 times which enabled us to use a lower voltage of 2V in order to achieve noticeable results during the actual drug delivery experiment performed in the points of low ionic resistance that are located on a human biceps, also the application of Vaseline on the experimental surface does not allow the decrease of a skin conductance for as long as 11 hours which enables us to do the drug delivery over a long period of time. Finally, the drug delivery was performed and tested by means of HPLC method.