Graduation Year
2024
Document Type
Thesis
Degree
M.S.P.H.
Degree Name
MS in Public Health (M.S.P.H.)
Degree Granting Department
Public Health
Major Professor
Xiaoming Liu, Ph.D.
Committee Member
Rays H. Jiang, Ph.D.
Committee Member
Bi Zhao, Ph.D.
Keywords
Creatinine, Periodontitis, Plasminogen, Precision Medicine, Stress
Abstract
Periodontal disease remains a global public health concern. Despite the availability of preventive and therapeutic strategies, the multifactorial nature of periodontitis complicates its understanding and management. Periodontal disease is associated with an increased risk of chronic conditions, including ischemic heart disease (IHD), gestational hypertension, respiratory diseases such as COPD and bronchitis, and various cancers, including kidney and pancreatic cancers. Moreover, individuals with diabetes, autoimmune diseases like lupus and Crohn’s disease, and osteoporosis are more likely to develop periodontitis. The ambiguity in the direction of causality between periodontal disease and its associated conditions poses challenges for effective treatment. Mendelian randomization offers a methodological approach to clarify these causal relationships, enabling targeted interventions that may reduce the incidence of related diseases. This paper examines the impact of blood metabolites, lifestyle factors, and nutritional factors using Mendelian randomization to explore the causal links between multiple exposures and the development of periodontal disease. The results of this study have the potential to contribute to personalized medicine by informing targeted prevention and treatment strategies for periodontal disease. Additionally, the identification of genetic variants associated with both exposure and periodontal disease could support further longitudinal studies to validate causal relationships. Ultimately, this research aims to advance precision medicine and could significantly impact the future of dental treatment approaches.
Scholar Commons Citation
Charles, Rhea, "Unravelling the Impact of Blood Metabolites, and Lifestyle Factors on Periodontal Disease Using Mendelian Randomization" (2024). USF Tampa Graduate Theses and Dissertations.
https://digitalcommons.usf.edu/etd/10605
