Graduation Year
2022
Document Type
Thesis
Degree
M.S.
Degree Name
Master of Science (M.S.)
Degree Granting Department
Chemistry
Major Professor
Edward Turos, Ph.D.
Committee Member
James Leahy, Ph.D.
Committee Member
Kirpal Bisht, Ph.D.
Committee Member
Jill Roberts, Ph.D.
Keywords
antimicrobial resistance, ESKAPE, MRSA, nosocomial, sulfur
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Staphylococcus aureus (VRSA) are increasing concerns in the medical community. In addition to the threat of Staphylococcus aureus, the increase in number and severity of infections caused by other antibiotic-resistant bacteria is problematic to human health, particularly among the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter). The antibiotics like the penicillins and cephalosporins used commonly to treat MRSA, VRSA, and ESKAPE pathogens have continued to decline in the effectiveness. Our laboratory has developed a number of new families of anti-MRSA and anti-VRSA antibacterial compounds. In this thesis, an additional series of compounds called S-alkyl thiosulfonate esters were examined. Twenty-eight S-alkyl thiosulfonates were synthesized, characterized spectroscopically, and twenty-three of those were examined for antibacterial activity against a panel of 6 pathogenic bacteria referred to as ESKAPE pathogens. Two compounds, S-propyl propanethiosulfonate (LB-21) and S-sec-butyl sec-butanethiosulfonate (LB-22) exhibited the highest activity against vancomycin-intermediate Staphylococcus aureus and vancomycin-resistant Staphylococcus aureus with an MIC50 value of 4 μg/mL and 2 μg/mL, respectively.
Scholar Commons Citation
Blume, Lindsay I., "Synthesis and Antibacterial Testing of Novel Thiosulfonate Compounds" (2022). USF Tampa Graduate Theses and Dissertations.
https://digitalcommons.usf.edu/etd/10281
