Graduation Year
2024
Document Type
Dissertation
Degree
Ph.D.
Degree Name
Doctor of Philosophy (Ph.D.)
Degree Granting Department
Chemistry
Major Professor
Jianfeng Cai, Ph.D.
Committee Member
Kirpal Bisht, Ph.D.
Committee Member
Li-June Ming, Ph.D.
Committee Member
Feng Cheng, Ph.D.
Keywords
coordination, hydrogen bonding, PROTACs, self-assembly
Abstract
Non-covalent interactions are everywhere in our material world. From the microstructures of organisms to the functional materials used in industrial production, whenever matter exists, there are non-covalent interactions between the molecules that build up the matter.The exploration of non-covalent forces helps people understand the intrinsic principles of life processes, it can be applied to create new supramolecular materials as well. Supramolecular chemistry is a research field focusing on the properties and applications of non-covalent interactions. Various non-covalent interactions, such as hydrogen bonds, metal-ligand coordination, π-π interaction, hydrophobic interaction, etc., are objects of research in supramolecular chemistry.
Not only supramolecular chemists, but also scientists studying other branches of chemistry are paying more and more attention to the study of non-covalent forces. Biochemists, especially the researchers engaged in drug development, focus on the non-covalent interactions which are ubiquitous in the human body, aiming at optimizing the properties of drugs and improving efficacy of therapy with the help of the interactions.
This paper includes an exploration of the role of non-covalent forces in supramolecular chemistry and the development of drug-like molecules. With the help of non-covalent interactions, novel macromolecules with unique properties were successfully constructed, and laboratory synthesized drug-like molecules could also bind with specific targets non-covalently, hopefully higher selectivity and lower dose treatment could be achieved in the future.
Scholar Commons Citation
Zhang, Zhanpeng, "Explorations on Non-Covalent Interactions: From Supramolecules to Drug-Like Molecules" (2024). USF Tampa Graduate Theses and Dissertations.
https://digitalcommons.usf.edu/etd/10267
