Presentation (Project) Title

Measuring Concordance Between Point of Care Testing and Central Laboratory Testing in the Fibroscan®-Aspartate Aminotransferase (FAST) Score

Mentor Information

Guy Neff (Department of Hepatology)

Presentation Format

Event

Abstract

The multitude of non-alcoholic steatohepatitis (NASH) clinical trials require diagnostics increasing in invasiveness culminating in liver biopsy have led to endeavors to expedite early serological measurements with point-of-care testing (POCT). As the device moved from the military front lines, the Piccolo Xpress® POCT is a quick user-friendly modality for acquiring accurate, reliable, and reproducible diagnostics for a fraction of the cost of conventional analysis. If the results of Piccolo Xpress are found to be indistinguishable from those produced by high-volume central laboratory testing (CLT), POCT may supplant the current box-and-ship paradigm. Echosens, a specialized ultrasound device to assist with identifying hepatic fat and flexibility has evolved. To assist with this device we examine a composite score combining ultrasound and AST that rapidly and reliably predicts fibrosis stage in NASH patients without the need for biopsy.

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Measuring Concordance Between Point of Care Testing and Central Laboratory Testing in the Fibroscan®-Aspartate Aminotransferase (FAST) Score

The multitude of non-alcoholic steatohepatitis (NASH) clinical trials require diagnostics increasing in invasiveness culminating in liver biopsy have led to endeavors to expedite early serological measurements with point-of-care testing (POCT). As the device moved from the military front lines, the Piccolo Xpress® POCT is a quick user-friendly modality for acquiring accurate, reliable, and reproducible diagnostics for a fraction of the cost of conventional analysis. If the results of Piccolo Xpress are found to be indistinguishable from those produced by high-volume central laboratory testing (CLT), POCT may supplant the current box-and-ship paradigm. Echosens, a specialized ultrasound device to assist with identifying hepatic fat and flexibility has evolved. To assist with this device we examine a composite score combining ultrasound and AST that rapidly and reliably predicts fibrosis stage in NASH patients without the need for biopsy.