C12N 15/113 (20130101)
Provided are methods and compositions for modulating the differentiation of a myeloid derived suppressor cell (MDSC). In particular, described herein are miR-142 polynucleotides and miR-223 polynucleotides that can be used to modulate differentiation of MDSCs. Increased differentiation of a MDSC population, or cells within an MDSC population, can be achieved by increasing the miR-142 and/or miR-223 polynucleotides in a MDSC.
Mohapatra, Shyam S.; Bharadwaj, Srinivas Nagaraj; and Mohapatra, Subhra, "Compositions and methods for modulating myeloid derived suppressor cells" (2017). USF Patents. 919.
University of South Florida