C07K 7/64 (20130101)
The present invention is directed to a novel class of antimicrobial agents called .gamma.-AApeptides. The current invention provides various categories of .gamma.-AApeptides, for example, linear .gamma.-AApeptides, cyclic .gamma.-AApeptides, and lipidated .gamma.-AApeptides. .gamma.-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. .gamma.-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed .gamma.-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.
Padhee, Shruti; Wu, Haifan; Niu, Youhong; and Cai, Jianfeng, "Gamma-AApeptides with potent and broad-spectrum antimicrobial activity" (2016). USF Patents. 902.
University of South Florida