A61K 31/4164 (20130101)
The subject invention pertains to uses of PKC-iota inhibitors for treatment of breast cancer. In one embodiment, the subject invention provides novel uses of 1H-imidazole-4-carboxamide, 5-amino-1-[2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl]-,[1R-(1.alp- ha., 2.beta., 3.beta., 4.alpha.)] (ICA-1) and related compounds for treatment of breast cancer. The compounds of the subject invention have potent anti-proliferative effects against human breast cancer cells. The compounds of the subject invention also inhibit the phosphorylation of IKK-.alpha./IKK-.beta., induce chromatin condensation, and/or induce DNA fragmentation in cancer cells.
Acevedo-Duncan, Mildred E.; Hill, Diondra D.; and Ostrov, David A., "Use of PKC-iota inhibitors for the treatment of breast cancer" (2016). USF Patents. 868.
University of South Florida