Document Type
Patent
Publication Date
August 2004
Patent Number
6781029
Abstract
A transgenic animal, preferably a mouse, that expresses human antichymotrypsin (ACT) in brain tissues is provided, together with animal tissue-derived cell lines and progeny animals of said transgenic animal. Progeny are obtained by mating the transgeny animal with select animal strains used as models of Alzheimer's disease, related neurological disorders, or amyloidogenic diseases. Methods utilizing the parent and progeny animals and cells derived therefrom are disclosed for testing compounds for use as anti-inflammatory drugs, inhibitors of amyloidogenesis, and/or inhibitors of tau protein pathology associated with Alzheimer's disease, in the treatment of a variety of neurological diseases.
Application Number
09/903,993
Recommended Citation
Nilsson, Lars; Potter, Huntington; and Arendash, Gary W., "Transgenic animal and methods" (2004). USF Patents. 761.
https://digitalcommons.usf.edu/usf_patents/761
Assignees
University of South Florida
Filing Date
07/13/2001
Primary/U.S. Class
800/14
