Document Type

Patent

Publication Date

February 2011

Patent Number

7892553

Abstract

The present invention pertains to nanoparticles, comprising a metal and/or polymer core, with 7-alpha hydroxylase, or an enzymatically active fragment thereof, nicotinamide adenine dinucleotide (NADH) and antibodies, or antibody fragments, specific for low density lipoprotein (LDL), attached to the core. The invention also concerns methods for reducing LDL cholesterol in a human or animal subject by administering nanoparticles of the invention. In a preferred embodiment, both circulating LDL and plasma cholesterol levels are reduced in the subject.

Application Number

11/799,367

Assignees

University of South Florida

Filing Date

04/30/2007

Primary/U.S. Class

424/172

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