Authors

William G. Kerr

Document Type

Patent

Publication Date

April 2012

Patent Number

8163710

Abstract

Inhibition of dendritic cell function in solid organ grafts or allogeneic bone marrow transplants prior to or during engraftment by blocking SH2-containing inositol phosphatase (SHIP) expression or function is taught as a method of abrogating immune rejection and thereby increasing the efficacy of engraftment of an allogeneic bone marrow transplant or solid organ allograft or xenograft. Also disclosed is a transgenic mouse having the genotype SHIP−/− which exhibits enhanced survival following mismatched allogeneic marrow grafts.

Application Number

12/651,809

Assignees

University of South Florida

Filing Date

01/04/2010

Primary/U.S. Class

514/44R

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