Document Type
Patent
Publication Date
October 2013
Patent Number
8569471
Abstract
The invention relates to methods and compositions for selectively directing stem cells to a target tissue within a subject using a system that employs one or more vectors that contain a gene switch/biosensor, a tissue-specific promoter, a gene encoding a stem cell-attracting chemokine, and a gene amplification system. In one embodiment, a stem cell-attracting chemokine is expressed in damaged tissue using a stimulus-responsive vector system. The stimulus can be a physiological stimulus associated with cell injury, such as hypoxia or elevated glucose levels, for example. Expression of the chemokine increases the trafficking of stem cells to the damaged tissue.
Application Number
13/299,991
Recommended Citation
Phillips, M. Ian and Tang, Yao Liang, "Stem cell beacon" (2013). USF Patents. 253.
https://digitalcommons.usf.edu/usf_patents/253
Assignees
University of South Florida
Filing Date
11/18/2011
Primary/U.S. Class
536/234
