The present invention relates to a series of markers and a method of determining cause of death post-mortem by quantifying thymus integrity. An examination of thymuses from human infants suffering mortal head trauma revealed a disruption of the cortical-medullary organization of the thymus, particularly involving dissolution of the cortical-medullary border. A similar result was obtained for related mouse and rat models. The human thymuses from head trauma cases also displayed a higher percentage of Ki67-positive thymocytes.
Blanck, George and Lloyd, Mark, "Method for quantitative assessment of thymus integrity" (2013). USF Patents. 247.
University of South Florida H. Lee Moffitt Cancer Center and Research Institute, Inc.