The present invention is directed to compositions and methods for treatment of ischemic diseases and conditions, particularly myocardial, CNS/brain and limb ischemia. More particularly, the present invention provides methods of treating disorders by administering monocytes obtained from blood, including umbilical cord blood, peripheral blood, or bone marrow to an individual in need of treatment, wherein the drug is administered to the individual at a time point specifically determined to provide therapeutic efficacy. In one embodiment, the cells are for injection into ischemic myocardium for the treatment of angina.
Sanberg, Paul R.; Hossne, Jr., Nelson Americo; Willing, Alison E.; and Invitti, Adriana, "Ischemic tissue cell therapy" (2014). USF Patents. 140.
Cryopraxis Criobiologia Ltda. Universidade Federal de Sao Paulo—UNIFESP University of South Florida