Document Type
Article
Publication Date
May 2022
Patent Number
11318155
CPC
A61K 31/7048, A61K 31/366, A61P 25/28
Abstract
Disclosed herein are compounds and methods for inhibiting Aha1 for the treatment of tauopathies and neurodegenerative diseases. The Aha1 inhibitor may reduce the interaction between Aha1 and Hsp90. The Aha1 inhibitor may reduce aggregation of tau protein. The Aha1 inhibitor may include a compound selected from KU-177, KU-174, and KU-308.
Application Number
16/486975
Recommended Citation
Dickey, Chad; Shelton, Lindsey; Blagg, Brian; Koren, John; and Blair, Laura, "Hsp90 activator Aha1 drives production of pathological tau aggregates" (2022). USF Patents. 1293.
https://digitalcommons.usf.edu/usf_patents/1293
Assignees
University of South Florida
Filing Date
02/23/2018
COinS
