Document Type
Article
Publication Date
June 2020
Patent Number
10675301
CPC
A61K 9/1075, A61K 33/30, A61K 47/124, A61K 31/722, C02F 1/50, C02F 2305/08, C02F 2303/04, B82Y 5/00
Abstract
A broad-based remediation mechanism against MRFs and alternative fecal indicators such as multidrug resistant Pseudomonas aeruginosa, including nanotechnology formulations and methodologies that may be used to develop novel mitigation strategies against certain drug resistant bacterial strains. The current invention relates to mitigation of drug resistant bacteria, for example in hospitals and in food animals, and to the identification. The invention uses hybrid nanomaterials comprising oligo-chitosan and zinc oxide formulated as nanoparticles and micelles. The invention also relates to the treatment of multi-drug resistant biofilms which mimic in vivo conditions. The inventors unexpectedly found unique properties of very small oligomers of chitosan that effectively mitigate MRF and alternative resistant strain-induced illnesses without compromising the balance of the beneficial flora in the physiological and ecological microenvironments. The combination of chitosan with zinc oxide demonstrated synergistic and unexpected effects in treating multi-drug resistant pathogens.
Application Number
16/247061
Recommended Citation
Mohapatra, Shyam S. and Limayem, Alya, "Chitosan oligomer and zinc oxide nanoparticle compositions for treating drug resistant bacteria and biofilm" (2020). USF Patents. 1172.
https://digitalcommons.usf.edu/usf_patents/1172
Assignees
University of South Florida
Filing Date
01/14/2019
