Methods of treating or preventing allergic or pulmonary diseases characterized by endothelial dysfunction with Alda-1 are presented. Treatment of pulmonary endothelial cells subjected to hyperoxia with Alda-1 showed an increase in ALDH2 activity and expression. Treatment with Alda-1 also illustrated a decrease in oxidative stress, a decrease in reactive oxygen species (ROS), a decrease in apoptosis, a decrease in inflammation and an enhancement of mitochondrial membrane potential.
Kolliputi, Narasaiah; Lockey, Richard F.; and Galam, Lakshmi, "ALDA-1 treatment and prevention of pulmonary disease" (2020). USF Patents. 1168.
University of South Florida