Combination of High Fat Diet and Chronic Stress Retracts Hippocampal Dendrites
Atrophy, Brain, CA3, High fat diet, Hippocampus, Psychological stress, Synergy
Adult male rats were fed a low or high fat diet and given psychosocial stress (crowded and unstable housing with daily predator exposure) for 3 weeks. Neither stress nor high fat diet, alone, produced dendritic atrophy; only the group given the combination of stress and high fat diet developed a reduction of the length and number of branch points of apical dendrites of CA3 neurons. These findings indicate that a synergy between high fat diet and stress caused a retraction of CA3 dendrites. The findings are consistent with work on peripheral (e.g., cardiovascular) systems demonstrating a synergy between stress and high fat diet, and are relevant toward understanding how diet and stress interact to adversely affect brain and memory processing.
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Citation / Publisher Attribution
NeuroReport, v. 16, issue 1, p. 39-43
Scholar Commons Citation
Baran, Sarah E.; Campbell, Adam M.; Kleen, Jonathon K.; Foltz, Cainan; Wright, Ryan L.; Diamond, David M.; and Conrad, Cheryl, "Combination of High Fat Diet and Chronic Stress Retracts Hippocampal Dendrites" (2005). Psychology Faculty Publications. 1338.