Correlation between Working Memory Deficits and Cortical Aß Deposition in Transgenic APP+PS1 Mice

Document Type


Publication Date



Alzheimer’s disease, Transgenic mice, Learning and memory, Radial arm water maze, Amyloid load, Aβ deposition

Digital Object Identifier (DOI)



Doubly transgenic mAPP+mPS1 mice (15–16 months) had impaired cognitive function in a spatial learning and memory task that combined features of a water maze and a radial arm maze. Nontransgenic mice learned a new platform location each day during 4 consecutive acquisition trials, and exhibited memory for this location in a retention trial administered 30 min later. In contrast, transgenic mice were, on average, unable to improve their performance in finding the hidden platform over trials. The cognitive performance of individual mice within the transgenic group were inversely related to the amount of Aβdeposited in the frontal cortex and hippocampus. These findings imply that mAPP+mPS1 transgenic mice develop deficits in cognitive ability as Aβ deposits increase. These data argue that radial arm water maze testing of doubly transgenic mice may be a useful behavioral endpoint in evaluating the functional consequences of potential AD therapies, especially those designed to reduce Aβ load.

Was this content written or created while at USF?


Citation / Publisher Attribution

Neurobiology of Aging, v. 22, issue 3, p. 377-385