Exposure to a Novel environment interferes with the induction of hippocampal primed burst potentiation in behaving rats

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exposure to novel environment, interference with of hippocampal primed burst potentiation induced by electrical stimulation, rats

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Examined primed burst (PB) potentiation induced by electrical stimulation that mimics hippocampal physiology. Stimulation of the hippocampal commissural afferents by a single priming pulse, followed 170 msec later by 4 pulses at 200 Hz, induced PB potentiation of the CA1 population spike. 59 recording sessions in 29 rats served as the database. PB potentiation occurred in only 15% of the 1st recording sessions. Incidence increased with continued stimulations: 30% with the 2nd, 75% with the 3rd, and 92% with the 4th–6th sessions. In additional studies of 21 rats, acclimation to the environment, rather than a kindling-like phenomenon, was identified as a precondition. Findings suggest that exposure of a rat to a novel environment results in a profound, but temporary, inhibition of hippocampal plasticity.

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Psychobiology, v. 18, issue 3, p. 273-281