Document Type
Article
Publication Date
2019
Digital Object Identifier (DOI)
https://doi.org/10.1155/2019/4106293
Abstract
In this paper, we used tongue coating to obtain metabolites in patients with coronary heart disease (CHD) and chronic renal failure (CRF). The metabolites were analyzed to discover the substance that serves as the underlying basis of the damp phlegm pattern. This analysis is based on the Traditional Chinese Medicine (TCM) theory of “different diseases have the same pattern.” The metabolic spectrum was obtained through the Gas Chromatography Mass Spectrometry coupling techniques and analyzed by searching the METLIN and HMDB databases. Some metabolites related to amino acids and glucose metabolism were identified in the tongue-coating samples from damp phlegm pattern patients by comparing them to nondamp phlegm pattern patients and healthy subjects. In addition, there were five common metabolites in the tongue-coating samples from CHD damp phlegm pattern patients compared to CRF damp phlegm pattern patients, which allowed us to understand the theory of “different diseases have the same pattern.” In the future, the metabolites identified in this study may be used as noninvasive and convenient biomarkers to distinguish the damp phlegm pattern of CHD and CRF patients.
Rights Information
This work is licensed under a Creative Commons Attribution 4.0 License.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Disease Markers, v. 2019, art. 4106293
Scholar Commons Citation
Hao, Yiming; Yuan, Xue; Yan, Jin; Pham, Minh; Rohlsen, Dekai; Qian, Peng; Cheng, Feng; and Wang, Yiqin, "Metabolomic Markers in Tongue-Coating Samples from Damp Phlegm Pattern Patients of Coronary Heart Disease and Chronic Renal Failure" (2019). Pharmacy Faculty Publications. 89.
https://digitalcommons.usf.edu/pharm_facpub/89
