cancer, cancer stem cell, anti-cancer treatment, cancer stem cell marker, cancer stem cell model
Digital Object Identifier (DOI)
Although cancer stem cells have been well characterized in numerous malignancies, the fundamental characteristics of this group of cells, however, have been challenged by some recent observations: cancer stem cells may not necessary to be rare within tumors; cancer stem cells and non-cancer stem cells may undergo reversible phenotypic changes; and the cancer stem cells phenotype can vary substantially between patients. Here the current status and progresses of cancer stem cells theory is illustrated and via providing a panoramic view of cancer therapy, we addressed the recent controversies regarding the feasibility of cancer stem cells targeted anti-cancer therapy.
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Citation / Publisher Attribution
Oncotarget, v. 6, issue 42, p. 44191-44206
Scholar Commons Citation
Wang, Tao; Shigdar, Sarah; Gantier, Michael P.; Hou, Yingchun; Wang, Li; Li, Yong; Shamaileh, Hadi Al; Yin, Wang; Zhou, Shu-Feng; Zhao, Xinhan; and Duan, Wei, "Cancer Stem Cell Targeted Therapy: Progress Amid Controversies" (2015). Pharmacy Faculty Publications. 82.