Early and Late C-peptide Responses during Oral Glucose Tolerance Testing Are Oppositely Predictive of Type 1 Diabetes in Autoantibody-positive Individuals
Document Type
Article
Publication Date
2020
Keywords
C-peptide, oral glucose tolerance test, type 1 diabetes
Digital Object Identifier (DOI)
https://doi.org/10.1111/dom.13982
Abstract
We examined whether the timing of the C-peptide response during an oral glucose tolerance test (OGTT) in relatives of patients with type 1 diabetes (T1D) is predictive of disease onset. We examined baseline 2-h OGTTs from 670 relatives participating in the Diabetes Prevention Trial-Type 1 (age: 13.8 ± 9.6 years; body mass index z-score: 0.3 ± 1.1; 56% male) using univariate regression models. T1D risk increased with lower early C-peptide responses (30–0 min) (χ2 = 28.8, P < 0.001), and higher late C-peptide responses (120–60 min) (χ2 = 23.3, P < 0.001). When both responses were included in a proportional hazards model, they remained independently and oppositely associated with T1D, with a stronger overall association for the combined model than either response alone (χ2 = 41.1; P < 0.001). Using receiver operating characteristic curve analysis, the combined early and late C-peptide response was more accurately predictive of T1D than area under the curve C-peptide (P = 0.005). Our findings demonstrate that lower early and higher late C-peptide responses serve as indicators of increased T1D risk.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Diabetes, Obesity and Metabolism, v. 22, issue 6, p. 997-1000
Scholar Commons Citation
Ismail, Heba M.; Becker, Dorothy J.; Libman, Ingrid; Herold, Kevan C.; Redondo, Maria J.; Atkinson, Mark A.; Cleves, Mario A.; Palmer, Jerry; and Sosenko, Jay, "Early and Late C-peptide Responses during Oral Glucose Tolerance Testing Are Oppositely Predictive of Type 1 Diabetes in Autoantibody-positive Individuals" (2020). Pediatrics Faculty Publications. 53.
https://digitalcommons.usf.edu/ped_facpub/53
