Document Type

Article

Publication Date

2011

Keywords

isoniazid, hepatotoxicity, latent tuberculosis infection

Abstract

Isoniazid (INH) monotherapy has gained widespread acceptance as an efficacious therapy for latent tuberculosis infection (LTBI) especially in low-prevalence settings. Although INH related hepatotoxicity is well recognized, progression to severe liver dysfunction requiring care at a transplant center remains unpredictable. We report the management of a five year-old girl who developed progressive liver failure due to INH prophylaxis. This highlights the potential severity of INH related hepatic injury and underscores the significance of vigilant clinical monitoring throughout the duration of the therapy in children.

Digital Object Identifier (DOI)

https://doi.org/10.4137/CMPed.S6406

Rights Information

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License

Citation / Publisher Attribution

Clinical Medicine Insights: Pediatrics, v. 5, p. 9-13

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Yes

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