Isoniazid-Induced Severe Hepatotoxicity: An Infrequent but Preventable Cause of Liver Failure in Children Treated for Latent Tuberculosis Infection

Authors

Dan Desrochers, University of South Florida
Regino P. González-Peralta, University of Florida
Daniel T. McClenathan, University of South Florida
Michael J. Wilsey Jr, University of South FloridaFollow
Allah Haafiz, University of Florida

Document Type

Article

Publication Date

2011

Keywords

isoniazid, hepatotoxicity, latent tuberculosis infection

Digital Object Identifier (DOI)

https://doi.org/10.4137/CMPed.S6406

Abstract

Isoniazid (INH) monotherapy has gained widespread acceptance as an efficacious therapy for latent tuberculosis infection (LTBI) especially in low-prevalence settings. Although INH related hepatotoxicity is well recognized, progression to severe liver dysfunction requiring care at a transplant center remains unpredictable. We report the management of a five year-old girl who developed progressive liver failure due to INH prophylaxis. This highlights the potential severity of INH related hepatic injury and underscores the significance of vigilant clinical monitoring throughout the duration of the therapy in children.

Rights Information

This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Clinical Medicine Insights: Pediatrics, v. 5, p. 9-13

Scholar Commons Citation

Desrochers, Dan; González-Peralta, Regino P.; McClenathan, Daniel T.; Wilsey, Michael J. Jr; and Haafiz, Allah, "Isoniazid-Induced Severe Hepatotoxicity: An Infrequent but Preventable Cause of Liver Failure in Children Treated for Latent Tuberculosis Infection" (2011). Pediatrics Faculty Publications. 17.
https://digitalcommons.usf.edu/ped_facpub/17