Title

Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia

Document Type

Article

Publication Date

2020

Keywords

parvovirus B19, heart transplant, pediatric, immunodeficiency, subcutaneous immunoglobulin

Abstract

We treated three pediatric cardiac transplant patients with chronic parvovirus viremia with high-dose intravenous immunoglobulin (HD-IVIG). One patient with severe T-cell lymphopenia suffered recurrent viremia and aseptic meningitis, which resolved remarkably when he was switched to high-dose hyaluronidase-facilitated subcutaneous immunoglobulin (HD-SCIG-Hy). We discuss the advantages of HD-SCIG-Hy vs HD-IVIG treatment for similar cases.

Digital Object Identifier (DOI)

https://doi.org/10.1093/ofid/ofaa076

Citation / Publisher Attribution

Open Forum Infectious Diseases, v. 7, issue 5, art. ofaa076

Was this content written or created while at USF?

Yes

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