Title
Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia
Document Type
Article
Publication Date
2020
Keywords
parvovirus B19, heart transplant, pediatric, immunodeficiency, subcutaneous immunoglobulin
Abstract
We treated three pediatric cardiac transplant patients with chronic parvovirus viremia with high-dose intravenous immunoglobulin (HD-IVIG). One patient with severe T-cell lymphopenia suffered recurrent viremia and aseptic meningitis, which resolved remarkably when he was switched to high-dose hyaluronidase-facilitated subcutaneous immunoglobulin (HD-SCIG-Hy). We discuss the advantages of HD-SCIG-Hy vs HD-IVIG treatment for similar cases.
Digital Object Identifier (DOI)
https://doi.org/10.1093/ofid/ofaa076
Citation / Publisher Attribution
Open Forum Infectious Diseases, v. 7, issue 5, art. ofaa076
Scholar Commons Citation
Cruz, Rachel J.; Dasso, Joseph F.; Duff, Carla; Krasnopero, Diane; Long, Zsofia; Ellison, Maryssa; Nieves, Daime; Sriaroon, Panida; Asante-Korang, Alfred; and Walter, Jolan, "Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia" (2020). Pediatrics Faculty Publications. 1.
https://digitalcommons.usf.edu/ped_facpub/1
Was this content written or created while at USF?
Yes
