In Vivo Disruption of Tolerogenic Cross-presentation Mechanisms Uncovers an Effective T-cell Activation by B-cell Lymphomas Leading to Antitumor Immunity

Document Type

Article

Publication Date

2006

Abstract

Bone marrow-derived antigen-presenting cells (APCs) play a central role in the induction of tolerance to tumor antigens expressed by B-cell lymphomas. Here we show that in vivo disruption of this APC-mediated tolerogenic mechanism unveils an intrinsic ability of malignant B cells to efficiently present tumor antigens to antigen-specific CD4+ T cells, resulting in a strong antitumor effect. This intrinsic antigen-presenting ability of malignant B cells is, however, overridden by tolerogenic bone marrow-derived APCs, leading instead to T-cell unresponsiveness and lack of antitumor effect. These results highlight the concept that therapeutic strategies aimed at enhancing the antigen-presenting function of B-cell lymphomas might not succeed unless the tolerogenic mechanisms mediated by bone marrow-derived APCs are disrupted in the first place.

Digital Object Identifier (DOI)

https://doi.org/10.1182/blood-2005-07-3014

Citation / Publisher Attribution

Blood, v. 7, p. 2871-2878

Was this content written or created while at USF?

Yes

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