Impact of Lympho-vascular Space Invasion on Tumor Characteristics and Survival Outcome of Women with Low-grade Serous Ovarian Carcinoma
low-grade serous, lymphovascular space invasion, ovarian cancer
Digital Object Identifier (DOI)
Background and Objectives: To examine association of lympho-vascular space invasion (LVSI) with clinico-pathological factors and to evaluate survival of women with low-grade serous ovarian carcinoma containing areas of LVSI.
Methods: This is a multicenter retrospective study examining consecutive cases of surgically treated stage I-IV low-grade serous ovarian carcinoma (n = 178). Archived histopathology slides for the ovarian tumors were reviewed, and LVSI was scored as present or absent. LVSI status was correlated to clinico-pathological findings and survival outcome.
Results: LVSI was seen in 79 cases (44.4%, 95% confidence interval [CI] 37.1-51.7). LVSI was associated with increased risk of omental metastasis (87.0% vs 64.9%, odds ratio [OR] 3.62, P = 0.001), high pelvic lymph node ratio (median 12.9% vs 0%, P = 0.012), and malignant ascites (49.3% vs 32.6%, OR 2.01, P = 0.035). On multivariable analysis, controlling for age, stage, and cytoreductive status, presence of LVSI in the ovarian tumor remained an independent predictor for decreased progression-free survival (5-year rates 21.0% vs 35.7%, adjusted-hazard ratio 1.57, 95%CI 1.06-2.34, P = 0.026). LVSI was significantly associated with increased risk of recurrence in lymph nodes (OR 2.62, 95%CI 1.08-6.35, P = 0.047).
Conclusion: LVSI in the ovarian tumor is associated with adverse clinico-pathological characteristics and decreased progression-free survival in women with low-grade serous ovarian carcinoma.
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Citation / Publisher Attribution
Journal of Surgical Oncology, v. 117, issue 2, p. 236-244
Scholar Commons Citation
Matsuo, Koji; Wong, Kwong-Kwok; Fotopoulou, Christina; Blake, Erin A.; Robertson, Sharon E.; Pejovic, Tanja; Frimer, Marina; Pardeshi, Vishakha; Hu, Wei; Choi, Jong-Sun; Sun, Charlotte C.; Richmond, Abby M.; Marcus, Jenna Z.; Hilliard, Maren A.M.; Mostofizadeh, Sayedamin; Mhawech-Fauceglia, Paulette; Abdulfatah, Eman; Post, Miriam D.; Saglam, Ozlen; Shahzad, Mian M.K.; Karabakhtsian, Rouzan G.; Ali-Fehmi, Rouba; Gabra, Hani; Roman, Lynda D.; Sood, Anil K.; and Gershenson, David M., "Impact of Lympho-vascular Space Invasion on Tumor Characteristics and Survival Outcome of Women with Low-grade Serous Ovarian Carcinoma" (2018). Obstetrics & Gynecology Faculty Publications. 33.