Document Type

Article

Publication Date

2013

Abstract

We tested the hypothesis that transient microinjury to the brain elicits cellular and humoral responses that stimulate hippocampal neurogenesis. Brief stereotaxic insertion and removal of a microneedle into the right hippocampus resulted in (a) significantly increased expression of granulocyte-colony stimulating factor (G-CSF), the chemokine MIP-1a, and the proinflammatory cytokine IL12p40; (b) pronounced activation of microglia and astrocytes; and (c) increase in hippocampal neurogenesis. This study describes immediate and early humoral and cellular mechanisms of the brain’s response to microinjury that will be useful for the investigation of potential neuroprotective and deleterious effects of deep brain stimulation in various neuropsychiatric disorders.

Digital Object Identifier (DOI)

https://doi.org/10.1155/2013/205878

Rights Information

Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.

Citation / Publisher Attribution

Stem Cells International, v. 2013, art. 205878

Was this content written or created while at USF?

Yes

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