Title

Increased Selenoprotein P in Choroid Plexus and Cerebrospinal Fluid in Alzheimer's Disease Brain

Document Type

Article

Publication Date

2015

Keywords

Alzheimer's disease, cerebrospinal fluid, choroid plexus, selenium, selenoprotein P, selenoproteins, Sepp1

Digital Object Identifier (DOI)

https://doi.org/10.3233/JAD-141755

Abstract

Subjects with Alzheimer's disease (AD) have elevated brain levels of the selenium transporter selenoprotein P (Sepp1). We investigated if this elevation results from increased release of Sepp1 from the choroid plexus (CP). Sepp1 is significantly increased in CP from AD brains in comparison to non-AD brains. Sepp1 localizes to the trans-Golgi network within CP epithelia, where it is processed for secretion. The cerebrospinal fluid from AD subjects also contains increased levels Sepp1 in comparison to non-AD subjects. These findings suggest that AD pathology induces increased levels of Sepp1 within CP epithelia for release into the cerebrospinal fluid to ultimately increase brain selenium.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Journal of Alzheimer's Disease, v. 44, issue 2, p. 379-383

Share

COinS