Title

Neutrophil-mediated Vascular Barrier Injury: Role of Neutrophil Extracellular Traps

Document Type

Article

Publication Date

2017

Keywords

endothelial barrier dysfunction, neutrophil extracellular traps, vascular hyperpermeability

Digital Object Identifier (DOI)

https://doi.org/10.1111/micc.12352

Abstract

Neutrophils play an essential role in host defense against infection or injury. While neutrophil activation is necessary for pathogen clearance and tissue repair, a hyperactive response can lead to tissue damage and microcirculatory disorders, a process involving complex neutrophil–endothelium cross talk. This review highlights recent research findings about neutrophil-mediated signaling and structural changes, including those induced by neutrophil extracellular traps, which ultimately lead to vascular barrier injury.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Microcirculation, v. 24, issue 3, art. e12352

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