Structural and Functional Properties of yersinia Pestis caf1 Capsular Antigen and Their Possible Role in Fulminant Development of Primary Pneumonic Plague
Bubonic Plague, Pneumonic Plague, Capsular Antigen Caf1, Molecular Adhesin, Conformational Stability
Digital Object Identifier (DOI)
Yersinia pestis capsular antigen Caf1 is shown to be a β-structural protein that in polymeric form possesses very high conformational stability. Different approaches show that a dimer is the minimal cooperative block of Caf1 adhesin. Caf1 dimer interacts effectively with IL-1 receptors of human macrophage and epithelial cells. The specificity of such interaction is confirmed by the inhibition of IL-1α binding by Caf1. The Caf1 role in pneumonic plague pathogenesis is discussed.
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Citation / Publisher Attribution
Journal of Proteome Research, v. 1, issue 4, p. 307-315
Scholar Commons Citation
Abramov, Vyacheslav M.; Vasiliev, Anatoly M.; Khlebnikov, Valentin S.; Vasilenko, Raisa; Kulikova, Natalia; Kosarev, Igor V.; Ishchenko, Alexander T.; Gillespie, Joel R.; Millett, Ian S.; Fink, Anthony L.; and Uversky, Vladimir N., "Structural and Functional Properties of yersinia Pestis caf1 Capsular Antigen and Their Possible Role in Fulminant Development of Primary Pneumonic Plague" (2002). Molecular Medicine Faculty Publications. 696.