Human α-fetoprotein as a Zn2+-binding Protein. Tight Cation Binding is Not Accompanied by Global Changes in Protein Structure and Stability
α-fetoprotein, Carcinoembryonic Protein, Protein Structure Structural Transition, Conformational Stability, Zn2+ Binding
Digital Object Identifier (DOI)
The binding of zinc to human α-fetoprotein (AFP) isolated from human umbilical cord serum was studied by fluorimetric Zn2+-titration. We found that the total number of strong binding sites for zinc on this protein was 5: AFP has one very strong (dissociation constant, KdKd
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Citation / Publisher Attribution
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, v. 1586, issue 1, p. 1-10
Scholar Commons Citation
Permyakov, Sergei E.; Oberg, Keith A.; Cherskaya, Alexandra M.; Shavlovsky, Michail M.; Permyakov, Eugene A.; and Uversky, Vladimir N., "Human α-fetoprotein as a Zn2+-binding Protein. Tight Cation Binding is Not Accompanied by Global Changes in Protein Structure and Stability" (2002). Molecular Medicine Faculty Publications. 682.