The Most Important Thing is The Tail: Multitudinous Functionalities of Intrinsically Disordered Protein Termini
Intrinsically Disordered Protein, Disordered Protein Terminus, Protein Function, Entropic Chain, Protein Interaction, Chaperone
Digital Object Identifier (DOI)
Many functional proteins do not have well-folded structures in their substantial parts, representing hybrids that possess both ordered and disordered regions. Disorder is unevenly distributed within these hybrid proteins and is typically more common at protein termini. Disordered tails are engaged in a wide range of functions, some of which are unique for termini and cannot be found in other disordered parts of a protein. This review covers some of the key functions of disordered protein termini and emphasizes that these tails are not simple flexible protrusions but are evolved to serve.
Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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Citation / Publisher Attribution
FEBS Letters, v. 587, issue 13, p. 1891-1901
Scholar Commons Citation
Uversky, Vladimir N., "The Most Important Thing is The Tail: Multitudinous Functionalities of Intrinsically Disordered Protein Termini" (2013). Molecular Medicine Faculty Publications. 532.