Not That Rigid Midgets and Not So Flexible Giants: On The Abundance and Roles of Intrinsic Disorder in Short and Long Proteins
Intrinsically Disordered Protein Protein Function Eukaryotic Proteome
Digital Object Identifier (DOI)
Intrinsically disordered proteins or proteins with disordered regions are very common in nature. These proteins have numerous biological functions which are complementary to the biological activities of traditional ordered proteins. A noticeable difference in the amino acid sequences encoding long and short disordered regions was found and this difference was used in the development of length-dependent predictors of intrinsic disorder. In this study, we analyze the scaling of intrinsic disorder in eukaryotic proteins and investigate the presence of length-dependent functions attributed to proteins containing long disordered regions.
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Citation / Publisher Attribution
Journal of Biological Systems, v. 20, issue 4, p. 471-511
Scholar Commons Citation
Howell, Mark; Green, Ryan; Killeen, Alexis Ann; Wedderburn, Lamar; Picascio, Vincent; Rabionet, Alejandro; Peng, Zhenling; Larina, Maya; Xue, Bin; Kurgan, Lukasz; and Uversky, Vladimir N., "Not That Rigid Midgets and Not So Flexible Giants: On The Abundance and Roles of Intrinsic Disorder in Short and Long Proteins" (2012). Molecular Medicine Faculty Publications. 515.